Staying in Shape with Formins

Staying in shape in Norway

SnapShot: Formins

See online version for legend and references. Autosomal-dominant nonsyndromic deafness (DFNA1), myeloproliferative defects, defects in T lymphocyte traffi cking and proliferation, tumor cell invasion, defects in natural killer lymphocyte function DIAPH2 (mDia3) Cdc42 Kinetochore Stable microtubule attachment to kinetochore for chromosome alignment Premature ovarian failure DIAPH3 (mDia2) Increa...

Formins at a glance.

Formins are conserved actin polymerization machines that have instrumental roles in controlling rearrangements of the actin cytoskeleton and have recently been shown to directly regulate microtubule dynamics. Here, and on the accompanying poster, we aim to organize a rapidly expanding body of literature on this diverse protein family, summarizing the common properties that apply to most formins...

Staying well with bipolar disorder.

OBJECTIVE The research aimed to investigate how people diagnosed with bipolar mood disorder avoided episodes of illness and managed to stay well. The research also examined the role that personal, social and environmental factors played in helping people with bipolar mood disorder to stay well. METHOD This project used a combination of qualitative research methods. The design contained three ...

Adhesion molecules in the stem cell niche--more than just staying in shape?

The expression of adhesion molecules by stem cells within their niches is well described, but what is their function? A conventional view is that these adhesion molecules simply retain stem cells in the niche and thereby maintain its architecture and shape. Here, we review recent literature showing that this is but one of their roles, and that they have essential functions in all aspects of the...